TapImmune, a clinical-stage immuno-oncology company developing peptide and gene-based immunotherapeutics for cancer and metastatic disease, announced the receipt of a $3.7 million grant from the U.S. Department of Defense (DoD). The grant is to be used in carrying out a Phase 2 clinical study on the company’s HER2/neu-targeted T-cell vaccine. The trial will enroll women diagnosed with an early form of breast cancer called ductal carcinoma in situ (DCIS). Should the results of the study prove to be successful, the vaccine has the potential to replace standard surgery and chemotherapy, possibly playing a key role in the routine immunization schedule…
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Angionetics Inc. reported that the FDA has granted Fast Track designation for the Phase III clinical investigation of Generx (Ad5FGF-4) cardiovascular angiogenic gene therapy. Angionetics is a biotechnology company focused on the clinical and commercial development of gene-based bio-therapeutics for the treatment of the almost 1.8 million patients in the U.S. who have late-stage coronary artery disease and refractory angina, as well as other medical conditions due to myocardial ischemia. Generx was developed as a one-time treatment for improving exercise tolerance in angina patients, a condition that is refractory to standard medical therapy and not amenable to conventional revascularization procedures such as coronary…
The Maryland Technology Development Corporation (TEDCO) announced that two companies received $400,000 in funding through its Life Science Investment Fund (LSIF) – one of TEDCO’s Seed Investment Funds. TEDCO is the go-to source for entrepreneurial support and guidance for start-ups and early-stage companies engaged in bringing innovative ideas to market. For over fifteen years, the organization has provided funding, mentoring and networking opportunities to support Maryland’s innovation ecosystem. It is frequently ranked as one of the most active seed/early-stage investors in the nation. “The Life Science Investment Fund exists to meet the needs of Maryland companies developing products addressing human health that require…
Guided Therapeutics, the maker of a rapid and painless testing platform based on its patented biophotonic technology, announced today that it has reached an agreement with Shandong Yaohua Medical Instrument Corporation in China for exclusive distribution, sales and manufacturing rights of the LuViva® Advanced Cervical Scan for China, Taiwan, Hong Kong and Macau. In addition to a previous payment of $50,000 made by Shandong Yaohua, the terms of the license agreement include a licensing fee by Shandong Yaohua of $1,000,000, the purchase of a minimum of ten LuViva® Advance Cervical Scan devices in 2017 and royalties for disposables based on…
CivaTech Oncology, Inc., Corporation, a North Carolina-based company focused on localized radiation therapy, submitted a Form D for a $2.72M debt financing. The date of first sale was December 9, 2015, where the company was able to fundraise $2.71 million, or 99.64% of the offering. On average, companies in similar fields sell 68.60% of the total offering amount. The total private offering amount was $2.72 million. The fundraising form was filed on December 16. 2016. CivaTech cited that the reason for the financing was to exclude salaries paid in the ordinary course of business.. The fundraising still has $9,780 remaining and is…
OncoTAb, Inc. announced that the company was named as a recipient of a $300,000 grant by the National Cancer Institute (NCI) to begin pre-clinical development of a targeted therapy for triple negative breast cancer. The company will use the funds to also continue its development of its patented antibody for therapeutic use in humans. The National Cancer Institute is under the larger umbrella of the National Institutes of Health (NIH), an agency of the Department of Health and Human Services. The grant is part of a Small Business Innovation Research (SBIR) Phase I contract OncoTAb co-founder and CEO Rahul Puri said of the award, “This…
Anavex Life Sciences Corp. announced the signing of a material transfer agreement with Biogen, wherein Biogen will test Anavex’s lead drug candidate, ANAVEX 2-73 in an oligodendrocyte precursor cell, OPC, differentiation assay. A satisfactory result from the OPC assay study may lead to an in vivo remyelination study using a chemical demyelination model. Christopher Missling, President and CEO of Anavex, is optimistic of the agreement, explaining, “These studies will examine the therapeutic role ANAVEX 2-73 may play in permitting remyelination in the brain.” The announcement caused shares of Anavex to spike 40%, to $ to $4.46. The science behind ANAVEX 2-73 makes it one of…
Tactical Therapeutics, Inc., an emerging growth oncology drug development company, presented results of two Phase IB trials of its lead drug Carboxyamidotriazole Orotate (CTO, PRAVITNIB) at the American Society of Clinical Oncology meeting in Chicago. Tactical is in the process of developing its patented drug, CTO, in patients with malignant glioma and glioblastoma (GBM). Treatment options are limited for GBM, which grows rapidly and spreads to the brain, making complete surgical resection difficult. GBM is highly resistant to DNA-modifying drugs and the standard combination of surgery, radiotherapy and chemotherap results in an overall survival of 12-15 months. As such, there remains…